GPHF-Minilab™ - Fact Sheet

Product Profile
Short Description:	Non-sophisticated, low-cost screening methods assembled as self-contained kit ready-packed for worldwide delivery by air and medicines testing on the spot. Verifies label claims on drug identity and content and detects counterfeit medicines containing the wrong, much to high, much to low or zero levels of active ingredients. Can be used outside a laboratory environment by those having some understanding of analytical chemistry, for example medical or pharmaceutical technicians. Manuals, basic lab ware, starter kit of chemicals and a collection of reference standards safeguard performance. Boosts medicines testing capacity and protects patients against falsified medicines of extreme poor quality infiltrating drug supply chains of governmental, private and faith-based health facilities in developing countries.
Working Principle:	Physical Testing: Visual Inspection Guide, Weight Verfication and Disintegration Test. Chemical Testing: Thin-Layer Chromatography.
Compounds Covered:	120 compounds taking into account medicines prevailing in developing countries for priority infectious diseases, mother & childcare, cardiovascular and diabetic disorders as well as some impurities: acetylsalicylic acid, aciclovir, albendazole, amikacin, aminophylline, amlodipine, amodiaquine, amoxicillin, ampicillin, apixaban, artemether, artesunate, atenolol, atovaquone, azithromycin, benzylpenicillin benzathine, benzylpenicillin sodium, benzylpenicillin potassium, benzylpenicillin procaine, bisoprolol, candesartan, capreomycin, captopril, carbamazepine, cefalexin, cefazolin, cefixime, cefpodoxime, cefotaxime, ceftriaxone, cefuroxime, cetirizine, chlorhexidine, chlorphenamine, chloramphenicol, chloroquine, ciprofloxacin, clarithromycin, clavulanic acid, clindamycin, clomifene, clopidogrel, cloxacillin, cycloserine, dapsone, dexamethasone, dexamethasone-21-phosphate, diclofenac, didanosine, diethylene glycol, dihydroartemisinin, doxycycline, efavirenz, empaglifozin, erythromycin, ethambutol, ethionamide, ethylene glycol, fluconazole, furosemide, gentamicin, glibenclamide, gliclazide, glimepiride, griseofulvin, halofantrine, hydralazine, hydrochlorothiazide, indinavir, irbesartan, isoniazid, kanamycin, lamivudine, levofloxacin, lisinopril, losartan, lumefantrine, mebendazole, mefenamic acid, mefloquine, metformin, methyldopa, metoclopramide, metronidazole, moxifloxacin, naproxen, nevirapine, nifedipine, ofloxacin, omeprazole, oseltamivir, p-aminosalicylic acid, paracetamol, phenoxymethylpenicillin, piperaquine, praziquantel, prednisolone, primaquine, proguanil, protionamide, pyrazinamide, pyrimethamine, pyronaridine, quinine, ranitidine, rifampicin, ritonavir, rivaroxaban, salbutamol, simvastatine, sitagliptin, stavudine, streptomycin, sulfadoxine, sulfamethoxazole, sulfamethoxypyrazine, telmisartan, tetracycline, valsartan, vildagliptin, warfarin, zidovudine.
Technical Details
TLC Kit Equipment:	1 Protective case incl. manuals and a collection of reference samples (83 x 52 x 29 cm, 25 kg, black with preformed dividers/pockets, wheels and extension handle).
Starter Kit Chemicals:	Capacity sufficient for about 1000 TLC runs. Coming in safety packs for air travel: 22 to 27 boxes (~ 25 kg)
Total Weight:	About 50 kg as ready-packed palette for worldwide delivery by air.
Storage:	Tropics-compatible but avoiding direct sunlight. No special storage area required for the quantities of chemicals supplied.
Shelf Life:	About 2 years for reference samples. May be shorter for antiretrovirals. Minimum 5 years for reagents and solvents in their original packaging.
Installation:	Out- and indoors. Bench top replaceable by office table. Deionized water is not required. For convenience purposes only: Power-driven hot plate when working indoors. Fits all sockets and voltages. Recommendations: Sufficient air ventilation, e.g. fan and open window, when using indoors. Access to running water for cleaning.
Costs
TLC Test Kit:	4700 € incl. manuals with method inventory on 120 compounds plus electronic pocket balance, all other lab equipment, solvents and other consumables for about 1000 test runs but without reference agents as control substances. The actual quotation is valid only.
Reference Agents:	between about 1200 - 1300 € * for a set of 26 antimicrobial reference agents: amoxicillin, ampicillin, azithromycin, benzylpenicillin potassium (serving benzylpenicillin benzathine/ procaine/ sodium), cefalexin, cefazolin, cefixime, cefotaxime, cefpodoxime, ceftriaxone, cefuroxime, chloramphenicol, ciprofloxacin, clarithromycin, clavulanic acid, clindamycin, cloxacillin, doxycycline, gentamicin, levofloxacin, metronidazole, ofloxacin, phenoxymethylpenicillin, sulfamethoxazole and tetracycline. There are currently no reference agents available for erythromycin stearate. between about 1100 - 1200 € * for a set of 12 antimalarial reference agents: amodiaquine, artemether, artesunate, atovaquone, chloroquine, dihydroartemisinin, lumefantrine, primaquine, proguanil, pyrimethamine, quinine and sulfadoxine. There are currently no reference agents available for halofantrine, mefloquine, piperaquine, pyronaridine and sulfamethoxazole. between about 390 - 410 € * for a set of 13 antimycobacterial reference agents: dapsone, ethambutol, ethionamide, isoniazid, kanamycin, levofloxacin, moxifloxacin, ofloxacin, p-aminosalicylic acid, protionamide, pyrazinamide, rifampicin and streptomycin. between about 160 - 170 € * for a set of 3 anthelminthic reference agents: albendazole, mebendazole and praziquantel. between about 70 - 75 € * for a set of 2 antifungal reference agents: fluconazole and griseofluvin. between about 360 - 380 € * for a set of 20 cardiovascular reference agents: amlodipine, atenolol, apixaban, bisoprolol, candesartan cilexetil, captopril, clopidogrel, furosemide, hydralazine, hydrochlorothiazide, irbesartan, lisinopril, losartan, methyldopa, nifedipine, rivaroxaban, simvastatin, telmisartan, valsartan and warfarin. between about 180 - 200 € * for a set of 7 antidiabetic reference agents: empaglifozin, glibenclamide, gliclazide, glimepiride, metformin, sitagliptin and vildagliptin. between about 85 - 95 € * for a set of 5 analgesic reference agents: acetylsalicylic acid, diclofenac, mefenamic acid, naproxen and paracetamol. between about 310 - 330 € * for a set of 6 antiallergic and antiasthmatic reference agents: aminophylline, cetirizine, chlorphenamine, dexamethasone, prednisolone and salbutamol. between about 200 - 220 € * for a set of 3 reference agents on gastrointestinal medicines: metoclopramide, omeprazole and ranitidine. between about 50 - 60 €* for other reference agents: carbamazepine, clomifene. between about 50 - 60 €* for impurities: diethylene glycol, ethylene glycol. Optional Items: between about 570 - 590 € * for a set of 9 anti(retro)viral reference agents: aciclovir, efavirenz, indinavir, lamivudine, nevirapine, oseltamivir, ritonavir, stavudine and zidovudine. Nota bene: minimum order quantities must be observed, which may make the costs about 6 times higher. between about 80 - 90 € * for one antiallergic reference agent: dexamethasone-21-phosphate. between about 410 - 440 € * for 2 antimycobacterial reference agents: amikacin disulfate and capreomycin disulfate. between about 270 - 280 € * for 3 antimalarial reference agents: mefloquine, pyronaridine and sulfamethoxypyrazine. between about 55 - 60 € * for the chlorhexidine antiseptic reference agent. * Costs are without VAT. Costs are depending on quantities and whether or not donated stock is available. The actual quotation is valid only.
Replacements:	Please ask for a price list when ordering single Minilab items for replacement. Minimum order: 10 €
Shipment:	In general, between 700 and 900 € for carriage and insurance for a single Minilab, the actual price, however, depending on the Minilab quantities and on the individual port and country of destination. Limited airfreight capacities may drive transport costs higher.
Clearance:	Clients responsibility: up to 1000 € without a waiver.
Payment Conditions
Settling of Invoice:	First time buyers before delivery in EURO via Technologie Transfer Marburg (TTM)
Bank Account:	Bank: Sparkasse Marburg Account No.: 11.03.44.89 Sorting Code: 533.500.00 SWIFT: HELA DE FF BIC-Code: HELA DE F1 MAR IBAN: DE 6553350000 0011034489
Reference Code:	GPHF-Minilab
Delivery
Transport:	Dangerous good delivery via cargo aircraft. Shipment via passenger aircraft on special request only (requires different packaging scheme).
Time of Delivery:	About six weeks from the time when the order has been received and the invoice been settled.
Delivered to:	Harbours or airports with known facilities for the reception of international good deliveries (Cargo aircraft terminal, Customs & Excise Office, etc.) based next to the client.
Additional Services
Reference Laboratory:	Access to reference laboratories at very favourable rates can be arranged by the Global Pharma Health Fund (GPHF).
Training:	In cases where training of doctors, pharmacists, pharmacy assistants and other healthcare professionals in the management of drug quality assurance is deficient, a one-week introductory course on the Minilab’s operation procedures is offered locally or in Germany by the Medical Mission Institute Würzburg, the German Medicines Aid action medeor or the GPHF-Minilab Project Manager. Inquiries via GPHF or its project partners.
Contacts
Product information by:	Global Pharma Health Fund (GPHF) Project Office, Rotlintstraße 75 60389 Frankfurt (Germany) Tel.: +49-69-46939-662 Fax: +49-69-46939852 Email:
Orders taken by:	Technologie Transfer Marburg (TTM) Industriestrasse 10, 35091 Coelbe, Germany Tel.: 0049-6421-87373-0 Fax: 0049-6421-87373-7 Email: ttm@ttm-germany.de TTM will also arrange for GPHF-Minilab™ shipment to a competent airport based next to the client.