GPHF-Minilab™ - Fact Sheet

Product Profile
Short Description: Non-sophisticated, low-cost screening methods assembled as self-contained kit ready-packed for worldwide delivery by air and medicines testing on the spot. Verifies label claims on drug identity and content and detects counterfeit medicines containing the wrong, much to high, much to low or zero levels of active ingredients. Can be used outside a laboratory environment by those having some understanding of analytical chemistry, for example medical or pharmaceutical technicians. Manuals, basic lab ware, starter kit of chemicals and a collection of reference standards safeguard performance. Boosts medicines testing capacity and protects patients against falsified medicines of extreme poor quality infiltrating drug supply chains of governmental, private and faith-based health facilities in developing countries.
Working Principle: Physical Testing: Visual Inspection Guide & Disintegration Test. Chemical Testing: Thin Layer Chromatography.
Drugs Covered: 90 compounds taking into account medicines prevailing in developing countries for priority diseases and mother & childcare: acetylsalicylic acid, albendazole, amikacin, aminophylline, aminosalicylate, amlodipine, amodiaquine, amoxicillin, ampicillin, artemether, artesunate, atenolol, atovaquone, azithromycin, benzylpenicillin benzathine, benzylpenicillin sodium, benzylpenicillin potassium, benzylpenicillin procaine, bisoprolol, capreomycin, captopril, cefalexin, cefazolin, cefixime, cefpodoxime, ceftriaxone, cefuroxime, cetirizine, chlorhexidine, chlorphenamine, clomifene, chloramphenicol, chloroquine, ciprofloxacin, clarithromycin, clavulanic acid, cloxacillin, cycloserine, dapsone, diclofenac, didanosine, dihydroartemisinin, doxycycline, efavirenz, erythromycin, ethambutol, ethionamide, furosemide, gentamicin, glibenclamide, griseofulvin, halofantrine, hydrochlorothiazide, indinavir, isoniazid, kanamycin, lamivudine, levofloxacin, lumefantrine, mebendazole, mefenamic acid, mefloquine, metformin, metronidazole, moxifloxacin, naproxen, nevirapine, ofloxacin, oseltamivir, paracetamol, phenoxymethylpenicillin, piperaquine, praziquantel, prednisolone, primaquine, proguanil, prothionamide, pyrazinamide, pyrimethamine, pyronaridine, quinine, rifampicin, salbutamol, stavudine, streptomycin, sulfadoxine, sulfamethoxazole, sulfamethoxypyrazine, trimethoprim, tetracycline, zidovudine.
 
Technical Details
TLC Kit Equipment: 1 Protective case incl. manuals and collection of authentic secondary reference standards (83 x 52 x 29 cm, 25 kg, black with preformed dividers/pockets, wheels and extension handle).
Starter Kit Chemicals: Capacity sufficient for about 1000 TLC runs. Coming in safety packs for air travel: 22 to 27 boxes (~ 25 kg)
Total Weight: About 50 kg as ready-packed palette for worldwide delivery by air.
Storage: Tropics-compatible but avoiding direct sunlight. No special storage area required for the quantities of chemicals supplied.
Shelf Life: About 2 years for authentic secondary reference standards. May be shorter for antiretrovirals. Minimum 5 years for reagents and solvents in their original packaging.
Installation: Out- and indoors. Bench top replaceable by office table. Deionized water is not required. For convenience purposes only: Power-driven hot plate when working indoors. Fits all sockets and voltages. Recommendations: Sufficient air ventilation, e.g. fan and open window, when using indoors. Access to running water for cleaning.
 
Costs
TLC Test Kit: 3422 € incl. manuals with method inventory on 90 drug compounds plus electronic pocket balance, all other lab equipment, solvents and other consumables for about 1000 test runs. The actual quotation is valid only.
Ref. Standards:
  • between about 550 - 580 € * for a set of 23 antimicrobials: amoxicillin, ampicillin, azithromycin, benzylpenicillin potassium, cefalexin, cefazolin, cefixime, ceftriaxone, cefuroxime, cefpodoxime, ciprofloxacin, clarithromycin, clavulanic acid, doxycycline, erythromycin, gentamicin, levofloxacin, metronidazole, ofloxacin, phenoxymethylpenicillin, sulfamethoxazole, trimethoprim and tetracycline (there are currently no reference standards available for chloramphenicol and cloxacillin)
  • between about 210 - 240 € * for a set of 12 antimalarials: amodiaquine, artesunate, artemether, atovaquone, chloroquine, dihydroartemisinin, lumefantrine, mefloquine, piperaquine, proguanil, pyronaridine and quinine (there are currently no reference standards available for halofantrine, primaquine, pyrimethamine, sulfadoxine and sulfamethoxypyrazine)
  • between about 340 - 370 € * for a set of 13 anti-TB drugs: 4-aminosalicylic acid (PAS), ciprofloxacin, cycloserine, ethambutol, ethionamide, isoniazid, kanamycin, levofloxacin, moxifloxacin, ofloxacin, prothionamide, pyrazinamide, rifampicin and streptomycin hemitrisulfate
  • between about 30 - 35 € * for a set of 3 anthelminthics: albendazole, mebendazole and praziquantel
  • between about 80 - 90 € * for 3 other anti-infective and antiseptic medicines: chlorhexidine, dapsone and griseofulvin
  • between about 50 - 55 € * for a set of 6 cardiovascular drugs: amlodipine, atenolol, bisoprolol, captopril, furosemide and hydrochlorothiazide
  • between about 120 - 125 € * for a set of 9 antiasthmatics, antiallergics and analgesics: acetylsalicylic acid, aminophylline, cetirizine, chlorphenamine, diclofenac, mefenamic acid, naproxen, paracetamol and prednisolone (there are currently no reference standards available for salbutamol)
  • between about 55 - 60 € * for 3 other medicines: clomifene, glibenclamid and metformin
  • Optional Items:
    • between about 2400 - 2600 € * for a set of 6 antiretrovirals: efavirenz, indinavir, lamivudine, nevirapine, stavudine and zidovudine (there is currently no reference standard available for didanosine)
    • between about 1600 - 1700 € * for 2 TB medicines: amikacin disulfate and capreomycin disulfate
    • between about 50 - 55 € * for the antiviral medicine oseltamivir
    • * Costs depending on quantities and whether or not donated stock is available. The actual quotation is valid only.
    Replacements: Please ask for a price list when ordering single Minilab items for replacement. Minimum order: 10 €
    Shipment: In general, between 700 and 900 € for carriage and insurance for a single Minilab, the actual price, however, depending on the Minilab quantities and on the individual port and country of destination.
    Clearance: Clients responsibility: up to 1000 € without a waiver.
    Payment Conditions
    Settling of Invoice: First time buyers before delivery in EURO via Technologie Transfer Marburg (TTM)
    Bank Account: Bank: Sparkasse Marburg
    Account No.: 11.03.44.89
    Sorting Code: 533.500.00

    SWIFT: HELA DE FF
    BIC-Code: HELA DE F1 MAR
    IBAN: DE 6553350000 0011034489
    Reference Code: GPHF-Minilab
     
    Delivery
    Transport: Dangerous good delivery via cargo aircraft. Shipment via passenger aircraft on special request only (requires different packaging scheme).
    Time of Delivery: About six weeks from the time when the order has been received and the invoice been settled.
    Delivered to: Harbours or airports with known facilities for the reception of international good deliveries (Cargo aircraft terminal, Customs & Excise Office, etc.) based next to the client.
     
    Additional Services
    Reference
    Laboratory:
    Access to reference laboratories at very favourable rates can be arranged by the Global Pharma Health Fund (GPHF).
    Training: In cases where training of doctors, pharmacists, pharmacy assistants and other healthcare professionals in the management of drug quality assurance is deficient, a one-week introductory course on the Minilab’s operation procedures is offered locally or in Germany by the Medical Mission Institute Würzburg, the German Medicines Aid action medeor or the GPHF-Minilab Project Manager. Inquiries via GPHF or its project partners.
     
    Contacts
    Product
    information by:
    Global Pharma Health Fund (GPHF)
    Project Office, Rotlintstraße 75
    60389 Frankfurt (Germany)
    Tel.: +49-69-46939-662
    Fax: +49-69-46939852
    Email:
    Orders taken by: Technologie Transfer Marburg (TTM)
    Auf der Kupferschmiede 1, 35091 Coelbe, Germany

    Tel.: 0049-6421-87373-0
    Fax: 0049-6421-87373-7
    Email: ttm@ttm-germany.de

    TTM will also arrange for GPHF-Minilab™ shipment to a competent airport based next to the client.